O3-S5.02 Frequent breakthrough genital HSV-2 shedding on standard and high dose valacyclovir
نویسندگان
چکیده
منابع مشابه
Frequent Genital HSV-2 Shedding among Women during Labor in Soweto, South Africa
BACKGROUND Despite high herpes simplex virus type 2 (HSV-2) incidence and prevalence among women in Africa, we are unaware of published neonatal herpes reports. To assess neonatal HSV transmission potential in South Africa, we investigated the frequency of the strongest risk factors: HSV acquisition in late pregnancy and HSV shedding during labor. METHODS Women admitted in early labor to a ho...
متن کاملHerpes simplex virus: a new era?
Herpes simplex virus type 2 (HSV-2) causes life-long infection with episodic reactivation. For decades, antiviral drugs, such as guanosine analogues (aciclovir and its prodrug valaciclovir), have been used to treat or prevent frequent and painful episodes. One outstanding question about HSV is why transmission is not stopped by these suppressive treatments. In The Lancet, Christine Johnston and...
متن کاملGenital HSV Shedding among Kenyan Women Initiating Antiretroviral Therapy
OBJECTIVES Genital ulcer disease (GUD) prevalence increases in the first month of antiretroviral treatment (ART), followed by a return to baseline prevalence by month 3. Since most GUD is caused by herpes simplex virus type 2 (HSV-2), we hypothesized that genital HSV detection would follow a similar pattern after treatment initiation. METHODS We conducted a prospective cohort study of 122 HSV...
متن کاملGenital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection.
CONTEXT Since herpes simplex virus type 2 (HSV-2) antibody tests have become commercially available, an increasing number of persons have learned that they have genital herpes through serologic testing. The course of natural history of HSV-2 in asymptomatic, seropositive persons is uncertain. OBJECTIVE To evaluate the virologic and clinical course of HSV genital shedding among individuals wit...
متن کاملStandard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials
BACKGROUND Skin and mucosal herpes simplex virus type 2 (HSV-2) shedding predominantly occurs in short subclinical episodes. We assessed whether standard-dose or high-dose antiviral therapy reduces the frequency of such shedding. METHODS HSV-2-seropositive, HIV-seronegative people were enrolled at the University of Washington Virology Research Clinic (WA, USA). We did three separate but compl...
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ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 2011
ISSN: 1368-4973
DOI: 10.1136/sextrans-2011-050109.128